A study of phosphocreatine
Previous studies have revealed that the decrease of bio-energetic metabolism may contribute to the occurrence of depression, while our team has found adenosine triphosphate ATP and phosphocreatine PCr to be fast-acting antidepressants in the depressed-animal model.
Thus, the primary function of this system is to act as a temporal energy buffer. The present study discussed the central and complex role that the phosphocreatine system performs in energy homeostasis in muscle cells, as well as its alterations in pathological conditions.
The second mechanism decreases the production of lysophosphoglycerides in hypoxic hearts, protects the sarcolemma of cardiac cells against ischemic damage, decreases the frequency of arrhythmias, and increases post-ischemic recovery of contractile function. At this level, your oxygen needs will exceed your oxygen supply, and your body will turn to alternative sources of energy, like phosphocreatine, to fuel explosive contractions.
Anaerobic contractions occur when you are performing a high-intensity exercise at 80 percent to 90 percent of your maximum heart rate MHR. During intense exercise, ATP is used up within seconds and needs to be replenished using phosphocreatine.
Phosphocreatine system definition
Creatine supplements may also help older people who typically experience drops in phosphocreatine from the middle years onward. Thus, the continuous supply of the high-energy phosphoryl bonds by PCr appears to contribute to the dynamic equilibrium of ATP consumption and ATP synthesis [ 27 ]. At this level, creatine supplements are considered safe and effective. Recent research on CrP has demonstrated positive therapeutic results in various clinical applications. Phosphocreatine is known as its quickest form of regeneration, by means of the enzyme creatine kinase. This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. With that being said, when combined with other supplements or taken at exceptionally higher doses, creatine has been known to cause liver, kidney, and even heart damage. Previous studies have revealed that the decrease of bio-energetic metabolism may contribute to the occurrence of depression, while our team has found adenosine triphosphate ATP and phosphocreatine PCr to be fast-acting antidepressants in the depressed-animal model. Free creatinine Cr was generated from its breakdown during muscle contraction. Feasibility outcomes will include percentages of patient eligibility, intention to use medication, willingness to participate, drug adherence, completion of the scheduled assessment, retention, drop-out, etc. Furthermore, 7-day intraperitoneal injections of ATP yielded AD-like effects to an extent similar to that of day treatment with imipramine [ 28 ].
Free creatinine Cr was generated from its breakdown during muscle contraction. Anaerobic Contractions Muscles use phosphocreatine during the first few seconds of an intense muscle contraction, such as during powerlifting or sprinting.
based on 92 review